Riboflavin (vitamin B2)

riboflavin-vitamin B2

Vitamins are food substances found only in things that grow, such as animals and plants. They are essential for our bodies to function properly. The human body cannot make vitamins. They must be ingested either as dietary supplements or better yet in food. Vitamins cannot replace food–they must be used in conjunction with food.

However, even if you eat a healthy diet, there is no guarantee that you will properly digest and absorb your foods and nutrients, which is why you must also have adequate gastrointestinal function if you want to absorb your vitamins. I recommend investigating your gastrointestinal function annually, by doing a GI Map Stool test, regardless if you have gastrointestinal symptoms or not. Riboflavin is also given intravenously in our Vital Health Drips IV Therapy.

Purchase the Gastrointestinal Stool Profile

It is crucial to have adequate gastrointestinal function, as I mentioned above, so that all of our vitamins and minerals can be absorbed and enter into the Krebs Cycle, which allows us to make energy (ATP). Often if even one nutrient is missing, energy production comes to a halt. You can see in the image below, where each nutrient is needed in the process and where it enters the cycle.

Krebs Cycle

Likewise, our vitamins and minerals must also enter the methylation cycle, for control of detoxification, cellular adaptability, and gene regulation. Thus, so many body processes are dependent on adequate intake, digestion and absorption of our nutrients. Below is a depiction of the methylation cycle.

Methylation Cycle

Vitamin B2, also known as riboflavin, is a component of enzymes involved in antioxidant function, energy production, detoxificaton, methionine metabolism and vitamin activation. It is a crucial B vitamin required for a significant amount of metabolic processes.


  • migraine headaches
  • anemia (iron)
  • cheilosis
  • chronic alcoholism
  • oxidative stress
  • mitochondrial dysfunction
  • low uric acid
  • oral and throat inflammation

Purchase the Micronutrient Testing Profile

Research proves that nutrients work synergistically so that the status of one nutrient typically impacts the status of other nutrients. Every vitamin and mineral should be evaluated within the context of other nutrients.


  • glutathione
  • homocysteine

Synergistic Nutrients:

  • vitamin B3 (niacin)
  • vitamin B6 (pyrodoxine)

Antagonistic Nutrients:

  • Calcium: might form a chelate with riboflavin, decreasing its absorption


  • oral contraceptives
  • tricyclic antidepressants
  • quinine
  • adriamycin
  • anti-psychotic medications


  • dairy: milk, cheese, eggs
  • whole grains
  • beef, chicken
  • wheat germ
  • fish
  • broccoli
  • asparagus
  • spinach
  • mushrooms
  • almonds

Purchase the Micronutrient Testing Profile




  • people with a certain gene (MTHR type TT) tend to respond well to vitamin B2 therapy for lowering blood pressure


  • needed to make glutathione that is needed to protect the body against free radical damage caused by elevated blood sugars
  • people with diabetes often have poor riboflavin metabolism
  • riboflavin 5-phosphate is the form desired and most supplments don’t use this form

Depression, Anxiety & Sleep:

  • low levels implicated in depression due to its role in methylation reactions in the brain


  • helps recycle folate into a usable methyl-donor form
  • precursor for FAD (flavin adenine dinucleotide) which assists methylation reactions


  • helps minimize pain associated with inflammation
  • detoxifies homocysteine, an amino acid that indirectly causes inflammation in various tissues

Purchase the Micronutrient Testing Profile